An Essential Role of Hrs/Vps27 in Endosomal Cholesterol Trafficking
The endosomal sorting complex required for transport (ESCRT) plays a crucial role Specialty Pipes in the degradation of ubiquitinated endosomal membrane proteins.Here, we report that Hrs, a key protein of the ESCRT-0 complex, is required for the transport of low-density lipoprotein-derived cholesterol from endosomes to the endoplasmic reticulum.Thi